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pentobarbital will reduce the level or outcome of tacrolimus by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.pentobarbital will minimize the level or impact of naloxegol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with potent CYP3A4 inducers just isn't advisable